Mouse ECG & motor function instruments - mouse model phenotyping

Publications describing application of

Mouse Specifics instruments

ECGenieTM ECG Screening system for

non-invasively recording ECGs in conscious mice.

1. Chu V, Otero JM, Lopez O, Morgan JP, Amende I, Hampton TG. Method for non-invasively recording electrocardiograms in conscious mice. BioMedCentral Physiology 2001, 1:6.

2. Chu V, Otero JM, Lopez O, Sullivan M, Morgan JP, Amende I, Hampton TG. Electrocardiographic findings in mdx mice: a cardiac phenotype of Duchenne muscular dystrophy. Muscle & Nerve 2002;513-519.

3. Min JY, Sullivan MF, Yan X, Feng X, Chu V, Wang JF, Amende I, Morgan JP, Philipson KD, Hampton TG. Overexpression of Na+/Ca2+ exchanger gene attenuates postinfarction myocardial dysfunction. Am J Physiol Heart Circ Physiol 2002 Dec;283(6):H2466-71.

4. Sutliff RL, Haase C, Russ R, Hoit BD, Morris R, Norman AB, and Lewis W. Cocaine Increases Mortality and Cardiac Mass in a Murine Transgenic Model of Acquired Immune Deficiency Syndrome. Lab Invest ; 2003; 83: 983.

5. Braun A, Trigatti BL, Post MJ, Sato K, Simons M, Edelberg JM, Rosenberg RD, Schrenzel M, Krieger M. Loss of SR-BI Expression Leads to the Early Onset of Occlusive Atherosclerotic Coronary Artery Disease, Spontaneous Myocardial Infarctions, Severe Cardiac Dysfunction, and Premature Death in Apolipoprotein E.Deficient Mice. Circ Res 2002; 90: 270-276.

6. Braun A, Zhang S, Miettinen HE, Ebrahim S, Holm TM, Vasile E, Post MJ, Yoerger DM, Picard MH, Krieger JL, Andrews NC, Simons M, Krieger M. Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein-E double knockout mouse. Proc Nat Acad Sci 2003; 100:7283-7288.

7. Svenson KL, Bogue MA, Peters LL. Invited review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains. J Appl Physiol 2003 94:1650-9.

8. Piskorksi K, Kale A, Chu V, Otero JM, Gladstone K, Mueller P, Amende I, and Hampton TG. Non-invasive physiology in conscious mice. 2002 Fourth World Congress Alternatives Congress Trust Proceedings. 2004, in press.

9. Amende I, Dubach JM, Piskorski K, Morgan JP, and Hampton TG. ECG Monitoring and Analyses in Mice. The Physiological Genomics of the Critically Ill Mouse in Basic Science for the Cardiologist Published by Kluwer Academic Publishers on mouse cardiovascular physiological genomics. 2004 in press.

10. Schuldt AJT, Hampton TG, Chu V, Vogler CA, Galvin N, Lessard ML, Barker JE. Cardiac anomalies in beta-glucuronidase (GUSB) null mice are corrected by non-ablative neonatal marrow transplantation. Proc Nat Acad Sci 2004.

DigiGaitÔ Imaging System

1. Hampton TG, Stasko MR, Kale A, Amende I, Costa ACS. Gait Dynamics in Trisomic Mice: Quantitative Neurological Traits of Down Syndrome. Physiology & Behavior, 2004, in press.

2. Piskorksi K, Kale A, Chu V, Otero JM, Gladstone K, Mueller P, Amende I, and Hampton TG. Non-invasive physiology in conscious mice. 2002 Fourth World Congress Alternatives Congress Trust Proceedings. 2004, in press.

3. Hampton TG, Stasko MR, Amende I, Kale A, Costa ACS. Gait dynamics in a mouse model of Down syndrome. Program No. 664.15. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002.

4. Hampton TG, Kale A, Gladstone K, Bridges J, Costa ACS, Amende I. How to characterize gait dynamics in mouse models of neuromuscular disease. Program No. 22.60. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002.

EverBeatÔ Mouse Heart Perfusion System

1. Hampton T, Kranias E, Morgan JP. Simultaneous measurement of intracellular calcium and ventricular function in the phospholamban-deficient mouse heart. Biochem Biophys Res Commun 1996; 226(3):836-841.

2. Hampton T, Amende I, Travers KE, Morgan JP. Intracellular calcium dynamics in mouse model of myocardial stunning. Am J Phys 1998; 43:H1821-H1827.

3. Cittadini A, Mantzoros C, Hampton T, Katz S, Travers K, Flier J, Morgan JP, Douglas P. Cardiovascular phenotype of transgenic mice with reduced brown fat. Circ Res 1999; 100(21):2177-2183.

4. Hampton T, Amende I, Li J, Park S, Morgan J, Simons M. Basic FGF reduces stunning via a NOS2-dependent pathway in coronary-perfused mouse hearts. Am J Phys 2000; 279:H260-268.

5. Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg RD, Hampton TG, Li J, Sellke F, Carmeliet P, and M Simons. PR39, a peptide regulator of angiogenesis. Nature Med 2000; 6:49-55.

6. Hampton T, Wang JF, Amende I, DeAngelis J, Philipson K, Morgan JP. Enhanced gene expression of the Na+-Ca2+ exchanger attenuates ischemic and contractile dysfunction. Am J Phys 2000; 279:H2846-2854.

7. Li J, Parovian C, Hampton TG, Metais C, Tkachenko E, Sellke FW, Simons M. Modulation of microvascular signaling by heparan sulfate matrix: studies in syndecan-4 transgenic mice. Microvasc Res 2002;64:38-46.

...better data from every mouse..