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The Arrhythmia Challenge
If you use mice in your target identification or preclinical studies, we invite you to take advantage of an opportunity to detect early cardiac rhythm disorders related to your drugs in your animal model by participating in The Arrhythmia Challenge.
Mouse Specifics will be demonstrating its new ECGenie, a non-invasive instrument for rapidly recording electrocardiograms (ECGs) in conscious mice, rats, and guinea pigs, throughout North America in July and August, 2004.
Investigators from academic, biotechnology, and pharmaceutical laboratories are invited to schedule FREE recordings of ECGs in their animal models and drug testing protocols. The protocol is defined by the investigator, and includes 6 ECG recordings; for example, a comparison of ECG indices in 3 wild-type mice and 3 transgenic mice, or the effects of an experimental compound compared to saline administration on QT interval changes in 3 conscious guinea pigs. All data will belong to the investigator for use in a manuscript, a grant application, or to reformulate compounds to correct any potential cardiotoxicities.
ECGenie reports heart rate, heart rate variability, and all of the ECG intervals, including the QT interval, in conscious mice, rats and guinea pigs. Neither anesthetic nor surgery is required - data are provided within minutes at a fraction of the cost of telemetry. The method has been described in several publications, most recently in a study about "The Metabolic and Cardiovascular Effects of Hyperthyroidism Are Largely Independent of ß-Adrenergic Stimulation"(Bachman et al., Endocrinology http://endo.endojournals.org/cgi/content/abstract/145/6/2767).
Should you choose to participate in the Arrhythmia Challenge, please review the dates that Mouse Specifics will be in your area. Select a day (Monday through Friday) and timeslot (8-10AM, 11-1PM, or 2-4PM) that fits your schedule. Please send an email to ShowMeQT@MouseSpecifics.com to schedule your study – please allow ~90 minutes for set-up, recordings, and analyses.
June 28-July 2: Boston and New England
July 12-July 16: Maryland, Pennsylvania, New Jersey, & New York
July 19-July 23: East North Central US (Wisconsin, Michigan,
llinois, & Ohio)
July 26-July30: Quebec & Ontario, Canada
August 2-August 6: San Francisco and Northern California cities
August 9-August 13: San Diego, La Jolla, & Southern California cities
August 16-August 20: Texas and Louisiana
August 23-August 28: Florida, Georgia, South Carolina and North Carolina
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